Manchester City manager Pep Guardiola has made two changes to his lineup following their 2-0 Champions League defeat to Juventus on Wednesday. Meanwhile, Manchester United boss Ruben Amorim has opted for four changes to the side that secured a 2-1 victory against Viktoria Plzen in the Europa League on Thursday.
For United, Harry Maguire, Rasmus Højlund, Mason Mount, and Manuel Ugarte come into the starting XI, replacing Tyrell Malacia, Casemiro, and Joshua Zirkzee. Marcus Rashford is absent from the squad entirely, while Alejandro Garnacho also misses out.
Starting Lineups
Manchester City:
Ederson; Walker, Dias, Gvardiol; Silva, Foden, Gündogan, Nunes, De Bruyne; Doku, Haaland.
Substitutes: Ortega, Stones, Kovačić, Grealish, Savinho, Simpson-Pusey, Mubama, O’Reilly, McAtee.
Manchester United:
Onana; Mazraoui, Maguire, De Ligt, Martínez, Dalot; Ugarte, Fernandes, Mount; Diallo, Højlund.
Substitutes: Bayındır, Lindelöf, Zirkzee, Malacia, Yoro, Eriksen, Casemiro, Antony, Mainoo.